製品の概要

  • 製品名Anti-Munc 13 antibody [Munc13-71]
    Munc 13 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [Munc13-71] to Munc 13
  • 特異性ab50566 recognises Munc13-1
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Rat
    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide:

    KAKFDGAQEKFNTYVTLK

    conjugated to KLH, corresponding to amino acids 10-27 of Rat Munc 13

  • ポジティブ・コントロール
    • Cytosolic rat brain S1 fraction

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab50566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 193 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 関連性Function: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Tissue specificity: Expressed in pancreatic islet cells (PubMed:12871971). Expressed in melanocytes (PubMed:23999003). Similarity: Belongs to the unc-13 family. Contains 3 C2 domains. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 MHD2 (MUNC13 homology domain 2) domain. Contains 1 phorbol-ester/DAG-type zinc finger. Domain: The C2 domains are not involved in calcium-dependent phospholipid binding. The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity.
  • 細胞内局在Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction; synapse, presynaptic cell membrane. Note: Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding
  • 参照データベース
  • 別名
    • KIAA1032 antibody
    • Munc13-1 antibody
    • Protein unc-13 homolog A antibody
    • UN13A antibody
    • UN13A_HUMAN antibody
    • Unc 13 homolog A antibody
    • Unc13a (gene name) antibody
    • Unc13a antibody
    • Unc13h1 (gene name) antibody
    see all

Anti-Munc 13 antibody [Munc13-71] (ab50566) 使用論文

ab50566 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab50566.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"