機能Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
配列類似性Belongs to the MUM1 family. Contains 1 PWWP domain.
ドメインThe PWWP domain mediates the interaction with nucleosomes.
翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
細胞内局在Nucleus. Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.