Anti-MUC4 抗体 [6A134] (ab85717)

製品の概要

  • 製品名Anti-MUC4 antibody [6A134]
    MUC4 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [6A134] to MUC4
  • アプリケーション適用あり: IHC-P, IHC-Frmore details
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Full length native MUC4 beta chain (purified) (Rat)

  • ポジティブ・コントロール
    • Colon and stomach tissue. Blood vessels and capillaries. Colon polyps, colon carcinoma tissue, gastric adenocarcinoma, lung carcinoma and ovarian mucinous adenocarcinoma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab85717 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 20 µg/ml.
IHC-Fr Use at an assay dependent concentration.

ターゲット情報

  • 機能May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
  • 組織特異性Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines.
  • 配列類似性Contains 1 AMOP domain.
    Contains 2 EGF-like domains.
    Contains 1 NIDO domain.
    Contains 1 VWFD domain.
  • 発生段階Expressed early in the primitive gut before respiratory and digestive epithelial cells have acquired their tissue and cell specificity. Expressed at the basal surface of the epithelium from week 14 to 26 weeks and then predominantly localized in only parietal cells. Immediately before birth, found in the cytoplasm of the mucous columnar epithelial cells. In the embryo expressed in skin, then disappears late in gestation.
  • 翻訳後修飾Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain.
    mucrnin-4 alpha chain is highly O-glycosylated.
    mucin-4 beta chain is predominantly N-glycosylated.
  • 細胞内局在Secreted; Cell membrane and Membrane. Secreted. Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Ascites sialoglycoprotein 1 antibody
    • Ascites sialoglycoprotein 2 antibody
    • Ascites sialoglycoprotein antibody
    • ASGP antibody
    • ASGP-1 antibody
    • ASGP-2 antibody
    • HSA276359 antibody
    • MUC 4 antibody
    • MUC-4 antibody
    • Muc4 antibody
    • MUC4_HUMAN antibody
    • Mucin 4 antibody
    • Mucin 4 cell surface associated antibody
    • Mucin 4 tracheobronchial antibody
    • Mucin-4 beta chain antibody
    • Pancreatic adenocarcinoma mucin antibody
    • Testis mucin antibody
    • Tracheobronchial mucin antibody
    • Tracheobronchial mucin Fragment antibody
    see all

Anti-MUC4 antibody [6A134] 画像

  • ab85717, at 20µg/ml, staining MUC4 in formalin-fixed, paraffin-embedded human colon tissue by Immunohistochemistry.
    A heat induced antigen retrieval step was performed using pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-MUC4 antibody [6A134] (ab85717) 使用論文

ab85717 has not yet been referenced specifically in any publications.

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Thank you for your inquiry.

I am sorry to confirm that (as stated in yesterday's email CCE xxxxx) we do not have any MUC4 or MUC13 antibodies that are suitable for mouse samples.

We expect a cross reaction to another species of an...

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