Anti-MUC2 抗体 [Ccp58] (ab118964)

製品の概要

  • 製品名Anti-MUC2 antibody [Ccp58]
    MUC2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [Ccp58] to MUC2
  • アプリケーション適用あり: IHC-Fr, WB, IHC-P, Flow Cyt, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, from a region of Human MUC2.

  • エピトープThe epitope was defined as GTQTP (GlyThrGlnThrPro).
  • ポジティブ・コントロール
    • Human colon, colon gastric cancer, salivary gland and intestine tissues; Human colon cancer cell line LS174.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab118964 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 540 kDa.
IHC-P 1/100.
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration.

ターゲット情報

  • 機能Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
  • 組織特異性Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
  • 配列類似性Contains 1 CTCK (C-terminal cystine knot-like) domain.
    Contains 1 TIL (trypsin inhibitory-like) domain.
    Contains 2 VWFC domains.
    Contains 4 VWFD domains.
  • 翻訳後修飾O-glycosylated.
    May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
    At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
  • 細胞内局在Secreted. In the intestine, secreted into the inner and outer mucus layers.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Intestinal mucin 2 antibody
    • Intestinal mucin-2 antibody
    • MLP antibody
    • MUC 2 antibody
    • MUC-2 antibody
    • Muc2 antibody
    • MUC2_HUMAN antibody
    • Mucin 2 antibody
    • Mucin 2 intestinal antibody
    • Mucin 2 intestinal/tracheal antibody
    • Mucin 2 oligomeric mucus/gel forming antibody
    • Mucin 2 precursor antibody
    • Mucin 2 tracheal antibody
    • Mucin like protein antibody
    • Mucin-2 antibody
    • Mucin2 antibody
    • SMUC antibody
    see all

Anti-MUC2 antibody [Ccp58] 画像

  • ab118964 at 1/100 staining MUC2 in Formalin-fixed, Paraffin-embedded Human colon tissue by Immunohistochemistry.
  • ab118964 at 1/100 staining MUC2 in Formalin-fixed, Paraffin-embedded Human intestine tissue by Immunohistochemistry.

Anti-MUC2 antibody [Ccp58] (ab118964) 使用論文

ab118964 has not yet been referenced specifically in any publications.

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