Anti-MUC17 抗体 (ab122184)
Key features and details
- Rabbit polyclonal to MUC17
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-MUC17 antibody -
製品の詳細
Rabbit polyclonal to MUC17 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
antigen sequence, corresponding to amino acids 4122-4262 of Human MUC17.
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ポジティブ・コントロール
- Human small intestine tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab122184の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Probably plays a role in maintaining homeostasis on mucosal surfaces. -
組織特異性
Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers. -
配列類似性
Contains 1 EGF-like domain.
Contains 1 SEA domain. -
翻訳後修飾
Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated. -
細胞内局在
Cell membrane and Secreted. Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 140453 Human
- SwissProt: Q685J3 Human
- Unigene: 271819 Human
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別名
- Membrane mucin MUC17 antibody
- MUC-17 antibody
- MUC-3 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab122184 は 4 報の論文で使用されています。
- Sun WW et al. Nanoarchitecture and dynamics of the mouse enteric glycocalyx examined by freeze-etching electron tomography and intravital microscopy. Commun Biol 3:5 (2020). PubMed: 31925335
- Al Amri WS et al. Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer. Mol Cancer Ther 19:945-955 (2020). PubMed: 31879365
- Li W et al. The Prognosis Value of PIWIL1 and PIWIL2 Expression in Pancreatic Cancer. J Clin Med 8:N/A (2019). PubMed: 31443431
- Yang CW et al. Genetic variations of MUC17 are associated with endometriosis development and related infertility. BMC Med Genet 16:60 (2015). IHC . PubMed: 26285705