Anti-MUC16 抗体 [X306] (Biotin) (ab90346)

製品の概要

  • 製品名Anti-MUC16 antibody [X306] (Biotin)
    MUC16 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [X306] to MUC16 (Biotin)
  • 標識Biotin
  • 特異性Specific to group A
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    MUC16 purified from Human ovarian carcinoma (MWt>1 million Da)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab90346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Predicted molecular weight: 2353 kDa.

ターゲット情報

  • 機能Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
  • 組織特異性Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
  • 配列類似性Contains 2 ANK repeats.
    Contains 56 SEA domains.
  • ドメインComposed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
  • 翻訳後修飾Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.
    Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.
    May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
    May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
  • 細胞内局在Cell membrane. Secreted > extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CA 125 antibody
    • CA-125 antibody
    • CA125 antibody
    • CA125 ovarian cancer antigen antibody
    • Cancer antigen 125 antibody
    • FLJ14303 antibody
    • MUC 16 antibody
    • MUC-16 antibody
    • MUC16 antibody
    • MUC16_HUMAN antibody
    • Mucin 16 antibody
    • Mucin 16 cell surface associated antibody
    • Mucin-16 antibody
    • Mucin16 antibody
    • Ovarian cancer related tumor marker CA125 antibody
    • Ovarian cancer-related tumor marker CA125 antibody
    • Ovarian carcinoma antigen CA125 antibody
    see all

Anti-MUC16 antibody [X306] (Biotin) (ab90346) 使用論文

ab90346 has not yet been referenced specifically in any publications.

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