製品の概要

  • 製品名Anti-MTMR14 antibody
    MTMR14 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MTMR14
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 264 and 415 of Human MTMR14 (AAH01674; UniProt ID: Q8NCE2 isoform 3).

  • ポジティブ・コントロール
    • WB: 293T, A431, Jurkat and Raji cell lysates IHC-P: MCF7 xenograft

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab102575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: for isoform 3, 60 kDa.
IHC-P 1/100 - 1/500. Antigen retrieval using heat mediated 10mM Citrate buffer or Tris-EDTA buffer (pH 8.0) is recommended.

ターゲット情報

  • 機能Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
  • 組織特異性Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
  • 関連疾患Defects in MTMR14 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • 配列類似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • 細胞内局在Cytoplasm. Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C3orf29 antibody
    • Egg derived tyrosine phosphatase homolog antibody
    • FLJ11546 antibody
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    • HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody
    • hEDTP antibody
    • hJumpy antibody
    • jumpy antibody
    • MTMR 14 antibody
    • MTMR14 antibody
    • MTMRE_HUMAN antibody
    • Myotubularin related protein 14 antibody
    • Myotubularin-related protein 14 antibody
    • NS5ATP4ABP1 antibody
    see all

Anti-MTMR14 antibody 画像

  • Anti-MTMR14 antibody (ab102575) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size : for isoform 3, 60 kDa
  • Immunohistochemical analysis of MTMR14 in paraffin embedded MCF7 xenograft, using ab102575 at a 1/250 dilution.

Anti-MTMR14 antibody (ab102575) 使用論文

ab102575 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab102575.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"