製品の概要

  • 製品名Anti-MTHFR antibody
    MTHFR 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MTHFR
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 21 and 218 of Human MTHFR (AAH53509).

  • ポジティブ・コントロール
    • 293T whole cell lysate

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96229 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 75 kDa.

ターゲット情報

  • 機能Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
  • パスウェイOne-carbon metabolism; tetrahydrofolate interconversion.
  • 関連疾患Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]. MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.
    Defects in MTHFR may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.
  • 配列類似性Belongs to the methylenetetrahydrofolate reductase family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 5 10 methylenetetrahydrofolate reductase (NADPH) antibody
    • 5 10 methylenetetrahydrofolate reductase antibody
    • Methylenetetrahydrofolate reductase (NAD(P)H) antibody
    • Methylenetetrahydrofolate reductase antibody
    • Methylenetetrahydrofolate reductase intermediate form antibody
    • MTHFR antibody
    • MTHR_HUMAN antibody
    see all

Anti-MTHFR antibody 画像

  • Anti-MTHFR antibody (ab96229) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size : 75 kDa

Anti-MTHFR antibody (ab96229) 使用論文

ab96229 has not yet been referenced specifically in any publications.

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