製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to MTHFD1L
  • 特異性
    Based on homology with the immunogen sequence, we believe this antibody will also react with MTHFD1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Cow, Dog, Pig
  • 免疫原

    Synthetic peptide:

    DTNDRFLRKITIGQ

    with a Cysteine residue linker, corresponding to internal sequence amino acids 578-591 of Human MTHFD1L protein (NP_056255.2).

  • ポジティブ・コントロール
    • Human cerebelum lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab116615 is purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG

アプリケーション

Our Abpromise guarantee covers the use of ab116615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 106 kDa.

ターゲット情報

  • 機能
    May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.
  • 組織特異性
    Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma.
  • パスウェイ
    One-carbon metabolism; tetrahydrofolate interconversion.
  • 配列類似性
    In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
    In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
  • ドメイン
    This monofunctional enzyme consists of two major domains: an N-terminal inactive methylene-THF dehydrogenase and cyclohydrolase domain and an active larger formyl-THF synthetase C-terminal domain.
  • 細胞内局在
    Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 10-formyl-THF synthetase antibody
    • C1TM_HUMAN antibody
    • Formyltetrahydrofolate synthetase antibody
    • formyltetrahydrofolate synthetase domain containing 1 antibody
    • FTHFSDC1 antibody
    • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like antibody
    • mitochondrial antibody
    • Monofunctional C1-tetrahydrofolate synthase antibody
    • MTC1THFS antibody
    • MTHFD1L antibody
    • RP1-292B18.2 antibody
    see all

画像

  • Anti-MTHFD1L antibody (ab116615) at 0.1 µg/ml + Human Cerebellum lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 106 kDa

プロトコール

参考文献

ab116615 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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