製品の概要

  • 製品名Anti-MTHFD1 antibody
    MTHFD1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to MTHFD1
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Xenopus laevis, Orangutan
  • 免疫原

    Synthetic peptide:

    RGDLNDCFIPCTPK

    , corresponding to internal sequence amino acids 137-150 of Human MTHFD1 (NP_005947.2)

  • ポジティブ・コントロール
    • Human Brain (substantia nigra) lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab79283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
  • 追加情報Peptide ELISA: Antibody detection limit dilution 1/1000.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 102 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 組織特異性Ubiquitous.
    • パスウェイOne-carbon metabolism; tetrahydrofolate interconversion.
    • 関連疾患Defects in MTHFD1 may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Genetic defects in MTHFD1 may affect the risk of spina bifida via the maternal rather than the embryonic genotype.
      Genetic variation in MTHFD1 could be associated with susceptibility to colorectal cancer (CRC) [MIM:114500].
    • 配列類似性In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
      In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
    • ドメインThis trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity.
    • 細胞内局在Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 5,10 methylenetetrahydrofolate dehydrogenase 5,10 methylenetetrahydrofolate cyclohydrolase,10 formyltetrahydrofolate synthetase antibody
      • C 1 tetrahydrofolate synthase cytoplasmic antibody
      • C1 tetrahydrofolate synthase cytoplasmic antibody
      • C1 THF synthase antibody
      • C1-THF synthase antibody
      • C1TC antibody
      • C1TC_HUMAN antibody
      • Cytoplasmic C 1 tetrahydrofolate synthase antibody
      • Formyltetrahydrofolate synthetase antibody
      • Methenyltetrahydrofolate cyclohydrolase antibody
      • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
      • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
      • Methylenetetrahydrofolate dehydrogenase antibody
      • MTHFC antibody
      • MTHFD antibody
      • MTHFD1 antibody
      • NADP dependent cyclohydrolase formyltetrahydrofolate synthetase antibody
      • OTTHUMP00000180657 antibody
      see all

    Anti-MTHFD1 antibody 画像

    Anti-MTHFD1 antibody (ab79283) 使用論文

    ab79283 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab79283.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"