製品の概要

  • 製品名Anti-MTHFD1 antibody
    MTHFD1 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to MTHFD1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length human MTHFD1 protein (AAH50420.1).

  • ポジティブ・コントロール
    • MTHFD1 transfected 293T cell lysate, human placenta cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab70203 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 95 kDa (predicted molecular weight: 102 kDa).

ターゲット情報

  • 組織特異性Ubiquitous.
  • パスウェイOne-carbon metabolism; tetrahydrofolate interconversion.
  • 関連疾患Defects in MTHFD1 may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Genetic defects in MTHFD1 may affect the risk of spina bifida via the maternal rather than the embryonic genotype.
    Genetic variation in MTHFD1 could be associated with susceptibility to colorectal cancer (CRC) [MIM:114500].
  • 配列類似性In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
    In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
  • ドメインThis trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 5,10 methylenetetrahydrofolate dehydrogenase 5,10 methylenetetrahydrofolate cyclohydrolase,10 formyltetrahydrofolate synthetase antibody
    • C 1 tetrahydrofolate synthase cytoplasmic antibody
    • C1 tetrahydrofolate synthase cytoplasmic antibody
    • C1 THF synthase antibody
    • C1-THF synthase antibody
    • C1TC antibody
    • C1TC_HUMAN antibody
    • Cytoplasmic C 1 tetrahydrofolate synthase antibody
    • Formyltetrahydrofolate synthetase antibody
    • Methenyltetrahydrofolate cyclohydrolase antibody
    • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
    • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
    • Methylenetetrahydrofolate dehydrogenase antibody
    • MTHFC antibody
    • MTHFD antibody
    • MTHFD1 antibody
    • NADP dependent cyclohydrolase formyltetrahydrofolate synthetase antibody
    • OTTHUMP00000180657 antibody
    see all

Anti-MTHFD1 antibody 画像

  • Anti-MTHFD1 antibody (ab70203) at 1/500 dilution + human placenta at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 102 kDa
    Observed band size : 95 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-MTHFD1 antibody (ab70203) at 1/500 dilution

    Lane 1 : MTHFD1 transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 102 kDa
    Observed band size : 95 kDa (why is the actual band size different from the predicted?)

Anti-MTHFD1 antibody (ab70203) 使用論文

ab70203 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab70203.
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