製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MTHFD1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-935 of Human MTHFD1 (AAH50420.1).

  • ポジティブ・コントロール
    • Human liver tissue lysate, Mouse liver tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab103698 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 102 kDa.

ターゲット情報

  • 組織特異性
    Ubiquitous.
  • パスウェイ
    One-carbon metabolism; tetrahydrofolate interconversion.
  • 関連疾患
    Defects in MTHFD1 may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Genetic defects in MTHFD1 may affect the risk of spina bifida via the maternal rather than the embryonic genotype.
    Genetic variation in MTHFD1 could be associated with susceptibility to colorectal cancer (CRC) [MIM:114500].
  • 配列類似性
    In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
    In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
  • ドメイン
    This trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 5,10 methylenetetrahydrofolate dehydrogenase 5,10 methylenetetrahydrofolate cyclohydrolase,10 formyltetrahydrofolate synthetase antibody
    • C 1 tetrahydrofolate synthase cytoplasmic antibody
    • C1 tetrahydrofolate synthase cytoplasmic antibody
    • C1 THF synthase antibody
    • C1-THF synthase antibody
    • C1TC antibody
    • C1TC_HUMAN antibody
    • Cytoplasmic C 1 tetrahydrofolate synthase antibody
    • Formyltetrahydrofolate synthetase antibody
    • Methenyltetrahydrofolate cyclohydrolase antibody
    • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
    • Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase antibody
    • Methylenetetrahydrofolate dehydrogenase antibody
    • MTHFC antibody
    • MTHFD antibody
    • MTHFD1 antibody
    • NADP dependent cyclohydrolase formyltetrahydrofolate synthetase antibody
    • OTTHUMP00000180657 antibody
    see all

画像

  • Anti-MTHFD1 antibody (ab103698) at 5 µg/ml + Human liver tissue lysate at 50 µg

    Predicted band size : 102 kDa
  • Anti-MTHFD1 antibody (ab103698) at 5 µg/ml + Mouse liver tissue lysate at 50 µg

    Predicted band size : 102 kDa
  • All lanes : Anti-MTHFD1 antibody (ab103698) at 5 µg/ml

    Lane 1 : MTHFD1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate


    Predicted band size : 102 kDa

プロトコール

参考文献

This product has been referenced in:
  • Audet-Walsh É  et al. The PGC-1a/ERRa Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Rep 14:920-931 (2016). Read more (PubMed: 26804918) »

See 1 Publication for this product

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