製品の概要

  • 製品名Anti-MTH1 antibody
    MTH1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MTH1
  • アプリケーション適用あり: ICC/IF, IHC-P, IHC-FoFr, IHC-Fr, WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic C-terminal peptide:

    CDTILDYTLREVDTV

    with a cysteine added for conjugation to KLH, corresponding to amino acids 143-156 of Human MTH1.

  • ポジティブ・コントロール
    • Hela cell extracts.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.05% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab98 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF 1/50 - 1/200.
IHC-P Use at an assay dependent concentration. PubMed: 21538080Human Tissue
IHC-FoFr Use at an assay dependent concentration. PubMed: 21538080Mouse Tissue
IHC-Fr 1/200.
WB 1/500. Predicted molecular weight: 18 kDa.

ターゲット情報

  • 機能Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
  • 組織特異性Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
  • 配列類似性Belongs to the Nudix hydrolase family.
    Contains 1 nudix hydrolase domain.
  • 発生段階In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
  • 翻訳後修飾The N-terminus is blocked.
  • 細胞内局在Cytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2-hydroxy-dATP diphosphatase antibody
    • 7 8 dihydro 8 oxoguanine triphosphatase antibody
    • 7 antibody
    • 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody
    • 8 oxo 7 8 dihydroguanosine triphosphatase antibody
    • 8 oxo dGTPase antibody
    • 8-dihydro-8-oxoguanine triphosphatase antibody
    • 8-oxo-dGTPase antibody
    • 8ODP_HUMAN antibody
    • MTH 1 antibody
    • MTH1 antibody
    • MutT human homolog 1 antibody
    • Nucleoside diphosphate linked moiety X motif 1 antibody
    • Nucleoside diphosphate linked moiety X type motif 1 antibody
    • Nucleoside diphosphate-linked moiety X motif 1 antibody
    • Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody
    • Nudix hydrolase 1 antibody
    • Nudix motif 1 antibody
    • Nudix type motif 1 antibody
    • NUDT 1 antibody
    • Nudt1 antibody
    see all

Anti-MTH1 antibody (ab98) 使用論文

This product has been referenced in:
  • Song XN  et al. Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and alzheimer's disease Patients. Neurochem Res 36:1558-65 (2011). IHC-P, IHC-FoFr ; Human, Mouse . Read more (PubMed: 21538080) »
  • Martin SA  et al. Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. EMBO Mol Med 1:323-37 (2009). WB . Read more (PubMed: 20049736) »

See all 4 Publications for this product

Product Wall

Thank you for you enquiry. We have not tested specificity of any isoforms of MTH1. I BLASTed the immunogen sequence. Unfortunately, I did not find any information comparing sequence homology of our MTH1 and the these isoforms. I'm sorry that I c...

Read More

We have tested ab98 with whole cell lysates of HeLa. We would therefore recommend HeLa Lysate - ab7898. Good luck with your experiments!

We have tested ab98 with whole cell lysates of HeLa. We would therefore recommend HeLa Lysate - ab7898. Good luck with your experiments!

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"