製品の概要

  • 製品名Anti-MTH1 antibody
    MTH1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to MTH1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-180 of Human MTH1

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab55527 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
    • 組織特異性Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
    • 配列類似性Belongs to the Nudix hydrolase family.
      Contains 1 nudix hydrolase domain.
    • 発生段階In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
    • 翻訳後修飾The N-terminus is blocked.
    • 細胞内局在Cytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 2-hydroxy-dATP diphosphatase antibody
      • 7 8 dihydro 8 oxoguanine triphosphatase antibody
      • 7 antibody
      • 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody
      • 8 oxo 7 8 dihydroguanosine triphosphatase antibody
      • 8 oxo dGTPase antibody
      • 8-dihydro-8-oxoguanine triphosphatase antibody
      • 8-oxo-dGTPase antibody
      • 8ODP_HUMAN antibody
      • MTH 1 antibody
      • MTH1 antibody
      • MutT human homolog 1 antibody
      • Nucleoside diphosphate linked moiety X motif 1 antibody
      • Nucleoside diphosphate linked moiety X type motif 1 antibody
      • Nucleoside diphosphate-linked moiety X motif 1 antibody
      • Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody
      • Nudix hydrolase 1 antibody
      • Nudix motif 1 antibody
      • Nudix type motif 1 antibody
      • NUDT 1 antibody
      • Nudt1 antibody
      see all

    Anti-MTH1 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab55527 MTH1 antibody at 1ug/ml. Predicted band size of immunogen is 46 kDa

    Anti-MTH1 antibody (ab55527) 使用論文

    ab55527 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab55527.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"