製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MTGR1
  • アプリケーション
    適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 401 and 598 of Human MTGR1.

  • ポジティブ・コントロール
    • 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji cell lysate. HeLa cells for IF.

法規制情報

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab96161 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 67 kDa.
ICC/IF 1/100 - 1/200.

ターゲット情報

  • 機能
    May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.
  • 組織特異性
    Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.
  • 配列類似性
    Belongs to the CBFA2T family.
    Contains 1 MYND-type zinc finger.
    Contains 1 TAFH (NHR1) domain.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AML1 MTG8 antibody
    • cbfa2t2 antibody
    • Core binding factor runt domain alpha subunit 2 translocated to 2 antibody
    • core-binding factor, runt domain, alpha subunit 2 antibody
    • DKFZp313F2116 antibody
    • EHT antibody
    • ETO homolog on chromosome 20 antibody
    • ETO homologous on chromosome 20 antibody
    • MTG 8 like protein antibody
    • MTG 8 related protein 1 antibody
    • MTG8 like protein antibody
    • MTG8 related protein 1 antibody
    • MTG8-like protein antibody
    • MTG8-related protein 1 antibody
    • MTG8R_HUMAN antibody
    • MTGR 1 antibody
    • Myeloid translocation gene related protein 1 antibody
    • Myeloid translocation related protein 1 antibody
    • Myeloid translocation-related protein 1 antibody
    • p85 antibody
    • Protein CBFA2T2 antibody
    • ZMYND 3 antibody
    • ZMYND3 antibody
    see all

画像

  • Anti-MTGR1 antibody (ab96161) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 67 kDa
  • Top panel: immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, using ab96161 at 1/200 dilution.
    Bottom panel: image merged with DNA probe.

参考文献

This product has been referenced in:
  • Nady N  et al. ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation. Elife 4:e10150 (2015). Read more (PubMed: 26523391) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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