製品の概要

  • 製品名Anti-MTCO2 antibody [4B12A5]
    MTCO2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [4B12A5] to MTCO2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Saccharomyces cerevisiae
  • 免疫原

    Saccharomyces cerevisiae Cytochrome C oxidase subunit II

  • ポジティブ・コントロール
    • Mitochondria from yeast membrane extract
  • 特記事項

    Product was previously marketed under the MitoSciences sub-brand.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 µg/ml. Predicted molecular weight: 26 kDa.

ターゲット情報

  • 機能Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
  • 関連疾患Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • 配列類似性Belongs to the cytochrome c oxidase subunit 2 family.
  • 細胞内局在Mitochondrion inner membrane.
  • Information by UniProt
  • 参照データベース
    • 別名
      • COII antibody
      • COX2 antibody
      • COX2_HUMAN antibody
      • COXII antibody
      • Cytochrome c oxidase II antibody
      • Cytochrome c oxidase polypeptide II antibody
      • Cytochrome c oxidase subunit 2 antibody
      • MT CO2 antibody
      • MT-CO2 antibody
      • MTCO2 antibody
      see all

    Anti-MTCO2 antibody [4B12A5] 画像

    • Anti-MTCO2 antibody [4B12A5] (ab110271) at 2 µg/ml + Mitochondria from yeast membrane extract at 10 µg

      Predicted band size : 26 kDa

    Anti-MTCO2 antibody [4B12A5] (ab110271) 使用論文

    This product has been referenced in:
    • Atkinson A  et al. Mzm1 influences a labile pool of mitochondrial zinc important for respiratory function. J Biol Chem 285:19450-9 (2010). Read more (PubMed: 20404342) »
    • Di Bella D  et al. Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nat Genet 42:313-21 (2010). Read more (PubMed: 20208537) »

    See all 26 Publications for this product

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    The immunogens are as follows;

    ab79393; A synthetic peptide corresponding to residues in human Cytochrome C oxidase subunit II
    ab109739; A synthetic peptide corresponding to residues in Human Cytochro...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"