製品の概要

  • 製品名Anti-MST1/MST2 antibody
    MST1/MST2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MST1/MST2
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat, Rabbit, Horse, Guinea pig, Cow, Turkey, Xenopus laevis, Chimpanzee, Zebrafish, Rhesus monkey, Gorilla, Tilapia, Orangutan, Xenopus tropicalis
  • 免疫原

    Synthetic peptide derived from the C terminal region of Human MST2 using the numbering given in Swiss Prot entry Q13188. The epitope is highly conserved with MST1.

  • ポジティブ・コントロール
    • Colon carcinoma, placenta, stomach adenocarcinoma.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab87322 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Perform antigen retrieval with tris-EDTA buffer pH9.0 before commencing with IHC staining protocol.
    Likely to work with frozen sections.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 関連性The human serine/threonine kinase, mammalian STE20 like kinase (MST), is considerably homologous to the budding yeast kinases, SPS1 and STE20, throughout their kinase domains. When stably expressed in HeLa cells, MST highly sensitizes the cells to death receptor mediated apoptosis by accelerating caspase 3 activation. These findings suggest that MST1 and MST2 play a role in apoptosis both upstream and downstream of caspase activation. MST1 is cleaved and activated by caspases during apoptosis and is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. Mammalian Sterile 20 Like 2 (MST2) is most similar to the previously identified MST1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in vitro kinase assay indicates that MST2 can phosphorylate an exogenous substrate, as well as itself, and phospho amino acid analysis indicates that it is a serine/threonine protein kinase.
    • 細胞内局在Cytoplasm. Nucleus. Note: The caspase cleaved form cycles between the nucleus and cytoplasm.
    • 参照データベース
    • 別名
      • DKFZp686A2068 antibody
      • FLJ90748 antibody
      • KRS1 antibody
      • KRS2 antibody
      • Mammalian STE20 like protein kinase 1 antibody
      • Mammalian STE20 like protein kinase 2 antibody
      • MST 1 antibody
      • MST 2 antibody
      • MST1 antibody
      • MST2 antibody
      • Serine/threonine kinase 3 (STE20 homolog yeast) antibody
      • Serine/threonine kinase 3 (Ste20 yeast homolog) antibody
      • Serine/threonine kinase 3 antibody
      • Serine/threonine kinase 4 antibody
      • Serine/threonine protein kinase 3 antibody
      • Serine/threonine protein kinase 4 antibody
      • Serine/threonine protein kinase Krs 1 antibody
      • Serine/threonine protein kinase Krs 2 antibody
      • STE20 like kinase MST1 antibody
      • STE20 like kinase MST2 antibody
      • STK 3 antibody
      • STK 4 antibody
      • STK3 antibody
      • STK4 antibody
      • YSK3 antibody
      see all

    Anti-MST1/MST2 antibody 画像

    • Detection of Human MST1/2 by immunohistochemistry on formalin-fixed, paraffin-embedded Human placenta tissue using ab87322 at a dilution of 1/250.
      Detection: DAB staining.
    • Detection of Human MST1/2 by immunohistochemistry on formalin-fixed, paraffin-embedded Human colon carcinoma tissue, using ab87322 at a dilution of 1/250.
      Detection: DAB staining.

    Anti-MST1/MST2 antibody (ab87322) 使用論文

    ab87322 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab87322.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"