The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the mouse mSin3A, catalog ab3479. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Histone deacetylase complex subunit Sin 3a
Histone deacetylase complex subunit Sin3a
Paired amphipathic helix protein Sin 3a
Paired amphipathic helix protein Sin3a
SIN3 homolog A
SIN3 homolog A transcription regulator
SIN3 homolog A transcription regulator (yeast)
SIN3 transcription regulator homolog A
Transcriptional co repressor Sin 3A
Transcriptional co repressor Sin3A
Transcriptional corepressor Sin3a
Transcriptional regulator SIN3A
機能Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST.