Anti-MSH3 抗体 [EPR4334(2)] (ab111107)


  • 製品名Anti-MSH3 antibody [EPR4334(2)]
    MSH3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR4334(2)] to MSH3
  • アプリケーション適用あり: IHC-P, ICC/IFmore details
    適用なし: WB
  • 種交差性
    交差種: Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human MSH3.

  • ポジティブ・コントロール
    • Human colon adenocarcinoma and tonsil tissues; SW480 cells.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファーpH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 50% Glycerol, 0.05% BSA
  • 精製度Tissue culture supernatant
  • ポリ/モノモノクローナル
  • クローン名EPR4334(2)
  • アイソタイプIgG
  • 研究分野


Our Abpromise guarantee covers the use of ab111107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Heat up to 98 degrees C, below boiling, and then let cool for 10-20 min.
ICC/IF 1/250 - 1/500.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
    • 関連疾患Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC) [MIM:608089].
    • 配列類似性Belongs to the DNA mismatch repair mutS family. MSH3 subfamily.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Divergent upstream protein antibody
      • DNA mismatch repair protein antibody
      • DNA mismatch repair protein Msh 3 antibody
      • DNA mismatch repair protein MSH3 antibody
      • DUC 1 antibody
      • DUC1 antibody
      • DUG antibody
      • DUP antibody
      • hMSH3 antibody
      • MGC163306 antibody
      • MGC163308 antibody
      • Mismatch repair protein 1 antibody
      • MRP 1 antibody
      • MRP1 antibody
      • MSH 3 antibody
      • MSH3 antibody
      • MSH3_HUMAN antibody
      • MutS homolog 3 (E. coli) antibody
      • MutS homolog 3 antibody
      see all

    Anti-MSH3 antibody [EPR4334(2)] 画像

    • ab111107 at 1/500 dilution staining MSH3 in Paraffin-embedded Human colon adenocarcinoma tissue by Immunohistochemistry.
    • ab111107 at 1/500 dilution staining MSH3 in Paraffin-embedded Human Tonsil tissue by Immunohistochemistry.
    • ab111107 at 1/250 dilution staining MSH3 in SW480 cells by Immunofluorescence.

    Anti-MSH3 antibody [EPR4334(2)] (ab111107) 使用論文

    ab111107 has not yet been referenced specifically in any publications.

    Product Wall

    I am afraid we do not have small samples of any of our antibodies. Antibody ab111107 may be specific for an epitope that exists only in the native conformation, as the western blot testing is carried out on reduced and denatured samples. We have not te...

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