製品の概要

  • 製品名
    MRS 2211
  • 製品の詳細
    Selective, competitive P2Y13 antagonist
  • 生理活性の詳細
    Selective, competitive P2Y13 antagonist (pA2 = 6.3). Displays >20-fold selectivity over P2Y1 and P2Y12 (IC50 > 10 μM for inhibition of human P2Y1 and human P2Y12 receptor-mediated phospholipase C responses).
  • 精製度
    > 95%

製品の特性

参考文献

This product has been referenced in:
  • Jacobson KA  et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal 5:75-89 (2009). Read more (PubMed: 18600475) »
  • Carrasquero LM  et al. P2X7 and P2Y13 purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes. J Neurochem 110:879-89 (2009). Read more (PubMed: 19457067) »
  • von Kügelgen I Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 110:415-32 (2006). Read more (PubMed: 16257449) »
  • Kim YC  et al. Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochem Pharmacol 70:266-74 (2005). Read more (PubMed: 15913566) »

See 1 Publication for this product

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