MRS 2179, P2Y1 antagonist (ab120414)
Key features and details
- Potent, selective P2Y1 antagonist
- CAS Number: 101204-49-3
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
MRS 2179, P2Y1 antagonist -
製品の詳細
Potent, selective P2Y1 antagonist -
生理活性の詳細
Potent, selective, competitive P2Y1 antagonist (Ki = 100 nM). Inhibits ATP induced glutamate release in vitro and inhibits ADP ability to evoke platelet shape change and aggregation.
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CAS 番号
101204-49-3 -
構造式
製品の特性
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体系名
2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate ammonium salt -
分子式
C11H17N5O9P2.xNH3 -
PubChem 登録番号
71308613 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
N.N.N.O=P(O)(O)OCC1OC(C[C@@H]1OP(=O)(O)O)n3cnc2c(NC)ncnc23 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab120414 は 4 報の論文で使用されています。
- Wu J et al. P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome. World J Gastroenterol 23:6339-6349 (2017). PubMed: 28974901
- Zeng J et al. P2Y13 receptor-mediated rapid increase in intracellular calcium induced by ADP in cultured dorsal spinal cord microglia. Neurochem Res 39:2240-50 (2014). PubMed: 25186167
- Campwala H et al. P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. J Cell Sci 127:4964-73 (2014). PubMed: 25271060
- Nandanan E et al. Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. J Med Chem 42:1625-38 (1999). PubMed: 10229631