生理活性の詳細Potent, selective, competitive P2Y1 antagonist (Ki = 100 nM). Inhibits ATP induced glutamate release in vitro and inhibits ADP ability to evoke platelet shape change and aggregation.
体系名2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate ammonium salt
保存方法Store at -20°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
溶解性Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Zeng JW et al. Inhibition of ATP-induced glutamate release by MRS2179 in cultured dorsal spinal cord astrocytes. Pharmacology82:257-63 (2008).
Read more (PubMed: 18841035) »
Kaiser RA & Buxton IL Nucleotide-mediated relaxation in guinea-pig aorta: selective inhibition by MRS2179. Br J Pharmacol135:537-45 (2002).
Read more (PubMed: 11815389) »
King BF 2-Chloro-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y1 receptor antagonist: commentary on Boyer et al. Br J Pharmacol135:1839-40 (2002).
Read more (PubMed: 11959784) »