MRP6 overexpression 293T lysate (whole cell) (ab94266)

製品の概要

  • 製品名MRP6 overexpression 293T lysate (whole cell)
  • 製品の詳細
    MRP6 overexpression lysate
  • 特記事項ab94266 is a 293T cell transfected lysate in which Human MRP6 has been transiently over-expressed using a pCMV-MRP6 plasmid. The lysate is provided in 1X Sample Buffer. Note: For more details about how the transfected lysate was prepared view preparation notes
  • アプリケーション適用あり: WBmore details

法規制情報

製品の特性

  • 背景Disease: Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE) [MIM:264800]. PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE). Function: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. Tissue specificity: Expressed in kidney and liver. Very low expression in other tissues.

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab94266 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution.

MRP6 overexpression 293T lysate (whole cell) 画像

  • ab94266 at 15µg/lane on an SDS-PAGE gel.
  • All lanes : Anti-MRP6 antibody (ab54826) at 1/500 dilution

    Lane 1 : MRP6 overexpression 293T lysate (whole cell) (ab94266)
    Lane 2 : 293T Non Transfected Lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-mouse IgG (H and L) HRP conjugated at 1/2500 dilution

MRP6 overexpression 293T lysate (whole cell) (ab94266) 使用論文

ab94266 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Questions for ab94266.
Please use the link above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"