製品の概要

  • 製品名Anti-MRP2 antibody
    MRP2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MRP2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Rabbit, Horse, Guinea pig, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 651-700 (TIQDVNLDIK PGQLVAVVGT VGSGKSSLIS AMLGEMENVH GHITIKGSIA) of Mouse MRP2 (NP_038834).

  • ポジティブ・コントロール
    • Mouse Spleen Lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 174 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
  • 組織特異性Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
  • 関連疾患Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
  • 配列類似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ABC30 antibody
    • abcC2 antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 2 antibody
    • ATP binding cassette subfamily C member 2 antibody
    • ATP-binding cassette sub-family C member 2 antibody
    • Canalicular multidrug resistance protein antibody
    • Canalicular multispecific organic anion transporter 1 antibody
    • CMOAT antibody
    • CMOAT1 antibody
    • cMRP antibody
    • DJS antibody
    • KIAA1010 antibody
    • MRP 2 antibody
    • MRP2_HUMAN antibody
    • Multidrug resistance associated protein 2 antibody
    • Multidrug resistance-associated protein 2 antibody
    see all

Anti-MRP2 antibody 画像

  • Anti-MRP2 antibody (ab110740) at 1 µg/ml + Mouse Spleen Lysate at 10 µg

    Predicted band size : 174 kDa

Anti-MRP2 antibody (ab110740) 使用論文

This product has been referenced in:
  • Canet MJ  et al. Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis. Drug Metab Dispos 43:266-72 (2015). Read more (PubMed: 25488932) »

See 1 Publication for this product

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Mouse Tissue sections (Liver)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Sodium Citrate, pH 6.0
Permeabilization No
Specification Liver
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 25°C
Fixative 10% Neutral Buffered Formalin
Username

Abcam user community

Verified customer

投稿 Nov 30 2015

Thank you for confirming those details.
As requested, I have generated a discount code for the anti-MRP2 antibody (ab110740) to be tested with canine protein. The discount code is as follows:
Discount code: xxxxxxxx Expiration date: 23rd Nove...

Read More

Thank you for contacting us and your interest in our products.
The immunogens used to raise the antibodies ab3373 and ab110740 against MRP2 both share higher than 85% homology with the canine protein. The ab3373 immunogen shares 88% homology and t...

Read More

Thank you very much for your inquiry and your patience while waiting for our answer.

I have inquired with the laboratories of the polyclonal antibodies, whether the immunogen sequence is conserved with the pig sequence. This would then provid...

Read More

Thank you for contacting Abcam regarding ab110740. I have confirmed that unfortunately, there are no available references for this antibody. I would like to inform you that all of our products are guaranteed under our Abpromise such that we are happy t...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"