Anti-MRG15 抗体 (ab37602)

製品の概要

• 製品名Anti-MRG15 antibody
  MRG15 一次抗体 製品一覧
• 製品の詳細
  Chicken polyclonal to MRG15
• アプリケーション適用あり: WBmore details
• 種交差性
  交差種: Mouse, Human
  
• 免疫原

  Synthetic peptide, corresponding to N terminal amino acids 1-235 of MRG15

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
• バッファーPreservative: None
  Constituents: PBS
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgY
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Acetylation

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • DNA Damage Response
  • Other

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Proto-oncogenes

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Tumor Suppressors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Co-factors

  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Acetylation
  • HAT

  • Cancer
  • Cell cycle
  • Cell cycle inhibitors
  • Other

関連製品

• Compatible Secondaries
  • Rabbit Anti-Chicken IgY H&L (FITC) (ab6749)
  • Rabbit Anti-Chicken IgY H&L (Biotin) (ab6752)
  • Rabbit Anti-Chicken IgY H&L (HRP) (ab6753)
  • Goat Anti-Chicken IgY H&L (HRP) (ab6877)
  • Goat Anti-Chicken IgY H&L (Biotin) preadsorbed (ab7117)

アプリケーション

ターゲット情報

• 機能Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
• 配列類似性Belongs to the MRG family.
• 細胞内局在Nucleus.

• Target information above from: UniProt accession Q9UBU8 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 10933 Human
  • Entrez Gene: 21761 Mouse
  • Entrez Gene: 627352 Mouse
  • Omim: 607303 Human
  • SwissProt: Q9UBU8 Human
  • SwissProt: P60762 Mouse
  • Unigene: 374503 Human
  • Unigene: 426209 Mouse

  • Unigene: 439775 Mouse
  • Unigene: 485088 Mouse

  see all
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