製品の概要
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製品名Anti-MRG15 antibody
MRG15 一次抗体 製品一覧 -
製品の詳細Chicken polyclonal to MRG15
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由来種Chicken
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アプリケーション適用あり: WBmore details
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種交差性交差種: Mouse, Human
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免疫原
Synthetic peptide, corresponding to N terminal amino acids 1-235 of MRG15
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
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バッファーPreservative: None
Constituents: PBS -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgY
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab37602 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
追加情報
WB: Recommended starting dilution for Western blot analysis is 1:500. Optimal working dilutions should be determined by the end user. Predicted molecular weight: 41 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
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配列類似性Belongs to the MRG family.
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細胞内局在Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 10933 Human
- Entrez Gene: 21761 Mouse
- Entrez Gene: 627352 Mouse
- Omim: 607303 Human
- SwissProt: Q9UBU8 Human
- SwissProt: P60762 Mouse
- Unigene: 374503 Human
- Unigene: 426209 Mouse
see all -
別名
- CG6363 antibody
- Eaf3 antibody
- Esa1p associated factor 3 homolog antibody
see all
プロトコール
参考文献
This product has been referenced in:
- Martrat G et al. Exploring the link between MORF4L1 and risk of breast cancer. Breast Cancer Res 13:R40 (2011). Read more (PubMed: 21466675) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"