製品の概要

  • 製品名Anti-MRC2 antibody
    MRC2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to MRC2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 105-215 of Human MRC2

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab56883 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).
    • 組織特異性Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
    • 配列類似性Contains 8 C-type lectin domains.
      Contains 1 fibronectin type-II domain.
      Contains 1 ricin B-type lectin domain.
    • ドメインC-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
      Fibronectin type-II domain mediates collagen-binding.
      Ricin B-type lectin domain contacts with the second C-type lectin domain.
    • 翻訳後修飾N-glycosylated.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • C-type lectin domain family 13 member E antibody
      • C-type mannose receptor 2 antibody
      • CD 280 antibody
      • CD280 antibody
      • CD280 antigen antibody
      • CLEC 13E antibody
      • CLEC13E antibody
      • ENDO 180 antibody
      • ENDO180 antibody
      • Endocytic receptor (macrophage mannose receptor family) antibody
      • Endocytic receptor 180 antibody
      • FLJ35911 antibody
      • KIAA0709 antibody
      • Macrophage mannose receptor 2 antibody
      • Mannose receptor C type 2 antibody
      • MRC 2 antibody
      • MRC2 antibody
      • MRC2_HUMAN antibody
      • UPAR-associated protein antibody
      • UPARAP antibody
      • Urokinase plasminogen activator receptor associated protein antibody
      • Urokinase receptor associated protein antibody
      • Urokinase receptor-associated protein antibody
      • Urokinase-type plasminogen activator receptor-associated protein antibody
      see all

    Anti-MRC2 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab56883 MRC2 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-MRC2 antibody (ab56883) 使用論文

    ab56883 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab56883.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"