製品の概要

  • 製品名Anti-MOX1 antibody
    MOX1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MOX1
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Cow, Dog
  • 免疫原

    Synthetic peptide derived from a region between residues 42-96 of Human MOX1.

  • ポジティブ・コントロール
    • Jurkat cell lysate. Human liver cells. Human stomach cells.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab23279 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.2 - 2 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 28 kDa).Can be blocked with MOX1 peptide (ab199250). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
  • 関連疾患Klippel-Feil syndrome 2, autosomal recessive
  • 配列類似性Contains 1 homeobox DNA-binding domain.
  • 細胞内局在Nucleus. Cytoplasm. Localizes predominantly in the nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Homeobox protein MOX-1 antibody
    • MEOX1 antibody
    • MEOX1_HUMAN antibody
    • Mesenchyme homeo box 1 antibody
    • Mesenchyme homeobox 1 antibody
    • MOX 1 antibody
    • MOX1 antibody
    see all

Anti-MOX1 antibody 画像

  • Anti-MOX1 antibody (ab23279) at 0.5 µg/ml + Jurkat cell lysate

    Secondary
    HRP conjugated anti-Rabbit IgG should be diluted in 1/50,000 - 100,000

    Predicted band size : 28 kDa
    Observed band size : 32 kDa (why is the actual band size different from the predicted?)
  • ab23279, at 4.0 - 8.0ug/ml staining human MOX1 in (human Liver) by Immunohistochemistry,Paraffin embedded tissue. Positive cells marked by arrows are hepatocytes. magnification 400 x.
  • ab23279, at 4.0 - 8.0ug/ml dilution, staining human MOX1 in human stomach by Immunohistochemistry, Paraffin embedded tissue. Cells with positive staining, marked by arrows, are Epithelial cells of Fundic Gland. Magnification 400 x.

Anti-MOX1 antibody (ab23279) 使用論文

ab23279 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"