Anti-MOX1/MEOX1 抗体 (ab105349)
Key features and details
- Rabbit polyclonal to MOX1/MEOX1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-MOX1/MEOX1 antibody
MOX1/MEOX1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to MOX1/MEOX1 -
由来種
Rabbit -
特異性
Predicted to not crossreact with MOX2. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human MOX1/MEOX1 (internal sequence).
Database link: P50221 -
ポジティブ・コントロール
- WB: Human liver tissue lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab105349の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 28 kDa.
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特記事項 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 28 kDa. |
ターゲット情報
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機能
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. -
関連疾患
Klippel-Feil syndrome 2, autosomal recessive -
配列類似性
Contains 1 homeobox DNA-binding domain. -
細胞内局在
Nucleus. Cytoplasm. Localizes predominantly in the nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 4222 Human
- Omim: 600147 Human
- SwissProt: P50221 Human
- Unigene: 438 Human
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別名
- Homeobox protein MOX-1 antibody
- MEOX1 antibody
- MEOX1_HUMAN antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab105349 は 3 報の論文で使用されています。
- Wang W et al. PPARa Ameliorates Doxorubicin-Induced Cardiotoxicity by Reducing Mitochondria-Dependent Apoptosis via Regulating MEOX1. Front Pharmacol 11:528267 (2020). PubMed: 33132907
- Wu B et al. Data on the involvement of Meox1 in balloon-injury-induced neointima formation of rats. Data Brief 16:266-270 (2018). PubMed: 29204471
- Dong K et al. Mesenchyme homeobox 1 mediates transforming growth factor-ß (TGF-ß)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors. J Biol Chem 293:8712-8719 (2018). PubMed: 29678882