製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Mouse
    • 配列
      RALMKVQVLRESPF
    • 領域
      295 to 308

関連製品

特性

Our Abpromise guarantee covers the use of ab4994 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse UCP 3, catalog ab3477. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • Mitochondrial uncoupling protein 3
    • SLC25A9
    • Solute carrier family 25 member 9
    • UCP 3
    • UCP3
    • UCP3_HUMAN
    • Uncoupling protein 3
    • Uncoupling protein 3 mitochondrial proton carrier
    see all
  • 機能
    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
  • 組織特異性
    Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.
  • 関連疾患
    Defects in UCP3 may be involved in obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • 配列類似性
    Belongs to the mitochondrial carrier family.
    Contains 3 Solcar repeats.
  • 細胞内局在
    Mitochondrion inner membrane.
  • Information by UniProt

Mouse UCP3 peptide (ab4994) 使用論文

This product has been referenced in:
  • Harmancey R  et al. Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart. J Biol Chem 290:30947-61 (2015). Read more (PubMed: 26555260) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry. Here is the protocol: BLOCKING WITH IMMUNIZING PEPTIDE (BL) PROTOCOL It is not uncommon to see more than one band in Western blotting when probing with a given antibody or to see more diffuse staining in immunolocali...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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