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別名
- 5031439C20
- AI326300
- EDG 2
- Endothelial differentiation gene 2
- Endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2
- GPCR 26
- Gpcr26
- Gpcr91
- GPR26
- Kdt2
- LPA 1
- LPA receptor 1
- LPA receptor EDG2
- LPA-1
- lpA1
- Lpar1
- LPAR1_HUMAN
- Lysophosphatidic acid receptor 1
- Lysophosphatidic acid receptor Edg-2
- Lysophosphatidic acid receptor EDG2
- MGC105279
- MGC29102
- Mrec1.3
- rec.1.3
- Ventricular zone gene 1
- vzg-1
- VZG1
see all
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機能
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.
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組織特異性
Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes.
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配列類似性
Belongs to the G-protein coupled receptor 1 family.
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細胞内局在
Cell surface. Cell membrane. Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.
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Information by UniProt