Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).
Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.
Contains 1 CW-type zinc finger.
Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.
Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.
Ver LS et al. The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication. J Virol89:10023-30 (2015).
Read more (PubMed: 26202233) »
Ichimura Y et al. Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy. Ann Rheum Dis : (2012).
Read more (PubMed: 22258483) »