Anti-MCT1/Monocarboxylic acid transporter 1 抗体 (ab93048)
Key features and details
- Rabbit polyclonal to MCT1/Monocarboxylic acid transporter 1
- Suitable for: ELISA
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-MCT1/Monocarboxylic acid transporter 1 antibody
MCT1/Monocarboxylic acid transporter 1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to MCT1/Monocarboxylic acid transporter 1 -
由来種
Rabbit -
アプリケーション
適用あり: ELISAmore details -
種交差性
交差種: Mouse
交差が予測される動物種: Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
Purity >90% -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab93048の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
ターゲット情報
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機能
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. -
組織特異性
Widely expressed in normal and in cancer cells. -
関連疾患
Symptomatic deficiency in lactate transport
Familial hyperinsulinemic hypoglycemia 7 -
配列類似性
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 20501 Mouse
- Entrez Gene: 25027 Rat
- SwissProt: P53986 Mouse
- SwissProt: P53987 Rat
- Unigene: 9086 Mouse
- Unigene: 6085 Rat
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別名
- FLJ36745 antibody
- HHF7 antibody
- MCT 1 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab93048 は 5 報の論文で使用されています。
- Buyse C et al. Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification. Metabolites 12:N/A (2022). PubMed: 35736489
- D'Adamo P et al. Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse. Metabolism 116:154463 (2021). PubMed: 33309713
- Benyahia Z et al. In Vitro and In Vivo Characterization of MCT1 Inhibitor AZD3965 Confirms Preclinical Safety Compatible with Breast Cancer Treatment. Cancers (Basel) 13:N/A (2021). PubMed: 33540599
- Wang D et al. Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs. Arthritis Res Ther 23:145 (2021). PubMed: 34020698
- Zhao D et al. Altered expression of lactate dehydrogenase and monocarboxylate transporter involved in lactate metabolism in broiler wooden breast. Poult Sci 99:11-20 (2020). PubMed: 32416791