The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000. Detects bands of approximately 136 and 170 kDa (predicted molecular weight: 136 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能May play a role in tumor suppression.
組織特異性Ubiquitously expressed. Highest levels in skeletal muscle.
関連疾患Note=A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL. Note=Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.