製品の概要

  • 製品名
    MMPIP
  • 製品の詳細
    mGlu7 allosteric antagonist
  • 生理活性の詳細
    Potent, selective allosteric antagonist at mGlu7 receptors. Inhibits agonist-induced intracellular calcium mobilisation and cAMP accumulation (IC50 values are 26 and 610 nM). Also displays intrinsic activity; increasing forskolin-induced cAMP accumulation in the absence of an agonist. Exhibits no significant activity at mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, and mGluR8. Also available in Kit: mGlu antagonists (ab120322)
  • 精製度
    > 98%

製品の特性

関連製品

参考文献

This product has been referenced in:
  • Niswender CM  et al. Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Mol Pharmacol 77:459-68 (2010). Read more (PubMed: 20026717) »
  • Li X  et al. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology 34:1783-96 (2009). Read more (PubMed: 19158667) »
  • Suzuki G  et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J Pharmacol Exp Ther 323:147-56 (2007). Read more (PubMed: 17609420) »

See all 3 Publications for this product

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