製品の概要

  • 製品名Anti-MMP9 antibody [2C3]
    MMP9 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [2C3] to MMP9
  • 特異性ab53296 targets MMP9.
  • アプリケーション適用あり: WB, Inhibition Assay, IHC-Fr, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Horse, Chimpanzee, Rhesus monkey
  • 免疫原

    Synthetic peptide:

    KLGLGADVAQVT

    conjugated to Ovalbumin, corresponding to C terminal amino acids 603-614 of Human MMP9

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53296 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 78 kDa.
Inhibition Assay Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-
    -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
  • 組織特異性Produced by normal alveolar macrophages and granulocytes.
  • 関連疾患Intervertebral disc disease
    Metaphyseal anadysplasia 2
  • 配列類似性Belongs to the peptidase M10A family.
    Contains 3 fibronectin type-II domains.
    Contains 4 hemopexin repeats.
  • ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻訳後修飾Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
    N- and O-glycosylated.
  • 細胞内局在Secreted, extracellular space, extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 82 kDa matrix metalloproteinase-9 antibody
    • 92 kDa gelatinase antibody
    • 92 kDa type IV collagenase antibody
    • CLG 4B antibody
    • CLG4B antibody
    • Collagenase Type 4 beta antibody
    • Collagenase type IV 92 KD antibody
    • EC 3.4.24.35 antibody
    • Gelatinase 92 KD antibody
    • Gelatinase B antibody
    • Gelatinase beta antibody
    • GelatinaseB antibody
    • GELB antibody
    • Macrophage gelatinase antibody
    • MANDP2 antibody
    • Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) antibody
    • Matrix Metalloproteinase 9 antibody
    • MMP 9 antibody
    • MMP-9 antibody
    • MMP9 antibody
    • MMP9_HUMAN antibody
    • Type V collagenase antibody
    see all

Anti-MMP9 antibody [2C3] (ab53296) 使用論文

This product has been referenced in:
  • Hackel D  et al. Transient opening of the perineurial barrier for analgesic drug delivery. Proc Natl Acad Sci U S A 109:E2018-27 (2012). Rat . Read more (PubMed: 22733753) »
  • Radjabi AR  et al. Thrombin Induces Tumor Invasion through the Induction and Association of Matrix Metalloproteinase-9 and {beta}1-Integrin on the Cell Surface. J Biol Chem 283:2822-34 (2008). Inhibition Assay ; Human . Read more (PubMed: 18048360) »

See all 3 Publications for this product

Product Wall



I can confirm that ab53296 Anti-MMP9 antibody [2C3] antibody is sold as tissue culture supernatant. Unpurified antibodies, such as those sold as tissue culture supernatant will not have a concentration stated on the datasheet. Antibody concen...

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I confirmed with the lab and am happy to let you know that the datasheet is correct and this antibody does not contain any sodium azide nor does it contain any other preservative.

Thank you for your message. I notice from our records that you have been waiting a long time for a resonse and Isincerely apologise for the long delay. Iappreciate your patience.

I contacted the originator and regrettably they have taken a l...

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Thank you for your enquiry.

We do have a large range of isotype control antibodies which can be found on the following page from our website:

http://www.abcam.com/index.html?c=4161

This includes several Mouse monoclonal...

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Thank you for your enquiry.

I can confirm that ab53296MMP9 antibody [2C3] is sold astissue culture supernatant. Unpurified antibodies, such as those sold as whole antiserum, ascites or tissue culture supernatant will not have a concentration...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"