Can degrade fibrillar type I, II, and III collagens.
Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Cytoplasmic granule. Secreted > extracellular space > extracellular matrix. Stored in intracellular granules.
Skjøt-Arkil H et al. Acute Myocardial Infarction and Pulmonary Diseases Result in Two Different Degradation Profiles of Elastin as Quantified by Two Novel ELISAs. PLoS One8:e60936 (2013).
Read more (PubMed: 23805173) »
Gabay O et al. Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model. Arthritis Rheum65:159-66 (2013).
Read more (PubMed: 23124828) »