機能Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.
組織特異性Expressed in B-cells.
配列類似性Belongs to the peptidase M10A family. Contains 4 hemopexin repeats.
ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
細胞内局在Secreted > extracellular space > extracellular matrix.