製品の概要

  • 製品名Anti-MMP26 antibody [EP1283Y]
    MMP26 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EP1283Y] to MMP26
  • アプリケーション適用あり: WBmore details
    適用なし: Flow Cyt,ICC,IHC-P or IP
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the C-terminus of human MMP26

  • ポジティブ・コントロール
    • 293 cell lysate.
  • 特記事項

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab81285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 30 kDa.
  • 追加情報Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • ターゲット情報

    • 関連性Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26, also known as Matrilysin 2, was first cloned from human fetal cells, and identified as an MMP most closely related to MMP7 (Matrilysin 1). The homology between MMP7 and MMP26 is low (only 38% identical), thus the functions are unlikely to be similar. Homology is much higher (48% identical) for the comparable region of MMP12, but MMP26 appears to have broader substrate specificity than does MMP12. MMP26, like MMP7, lacks the hemopexin domain common to the other MMPs, but contains a Propeptide domain, cysteine switch activation site, followed by a catalytic domain, and a short vestige of the hinge region. MMP26 is apparently not glycosylated, and is a secreted MMP. Tissue analysis shows MMP26 most strongly in placenta and uterus, but also in kidney cells, lung cells, lymphocytes and lung or endometrial carcinoma cells. MMP26 is proteolytically active, cleaving casein in zymograms, and gelatin, a1PI, fibrinogen, fibronectin, vitronectin, type IV collagen, and apparently activating MMP9. The proteolytic activity was blocked by TIMP1 and TIMP2. MMP26 does not appear to be produced by most normal quiescent cells, but treatment of many cell types with the phorbol ester TPA, or IL1 stimulates production of MMP26.
    • 細胞内局在Secreted
    • 参照データベース
    • 別名
      • Endometase antibody
      • Matrilysin 2 antibody
      • Matrix Metalloproteinase 26 antibody
      • MMP 26 antibody

    Anti-MMP26 antibody [EP1283Y] 画像

    • Anti-MMP26 antibody [EP1283Y] (ab81285) at 1/500 dilution + 293 cell lysate at 10 µg

      Secondary
      HRP conjugated goat anti-rabbit at 1/2000 dilution

      Predicted band size : 30 kDa
      Observed band size : 18 kDa (why is the actual band size different from the predicted?)

    Anti-MMP26 antibody [EP1283Y] (ab81285) 使用論文

    ab81285 has not yet been referenced specifically in any publications.

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