製品の概要

  • 製品名
    Anti-MMP19 antibody, prediluted
    MMP19 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MMP19, prediluted
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    非交差種: Mouse, Rat
  • 免疫原

    Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (Human) (N terminal).

  • ポジティブ・コントロール
    • Placenta.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab15477 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報
    IHC-P: Ready to use for 10 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
    • 組織特異性
      Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.
    • 関連疾患
      May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.
    • 配列類似性
      Belongs to the peptidase M10A family.
      Contains 4 hemopexin-like domains.
    • ドメイン
      The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • 翻訳後修飾
      Activated by autolytic cleavage after Lys-97.
    • 細胞内局在
      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Matrix metalloproteinase 18 antibody
      • Matrix metalloproteinase 19 antibody
      • Matrix metalloproteinase RASI antibody
      • Matrix metalloproteinase-18 antibody
      • Matrix metalloproteinase-19 antibody
      • MMP 18 antibody
      • MMP 19 antibody
      • MMP-18 antibody
      • MMP-19 antibody
      • MMP18 antibody
      • MMP19 antibody
      • MMP19_HUMAN antibody
      • RASI 1 antibody
      • RASI antibody
      • RASI1 antibody
      see all

    画像

    • ab15477 staining MMP19 in human placenta by Immunohistochemistry (FFPE-sections).

    プロトコール

    参考文献

    This product has been referenced in:
    • Ishikawa A  et al. Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia. Neurosci Res 59:406-12 (2007). IHC-P ; Human . Read more (PubMed: 17889387) »

    See 1 Publication for this product

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