製品の概要

  • 製品名Anti-MMP19 antibody
    MMP19 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to MMP19
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length Human protein (NP_002420.1)

  • ポジティブ・コントロール
    • HeLa cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab89689 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa.

ターゲット情報

  • 機能Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
  • 組織特異性Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.
  • 関連疾患May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.
  • 配列類似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻訳後修飾Activated by autolytic cleavage after Lys-97.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Matrix metalloproteinase 18 antibody
    • Matrix metalloproteinase 19 antibody
    • Matrix metalloproteinase RASI antibody
    • Matrix metalloproteinase-18 antibody
    • Matrix metalloproteinase-19 antibody
    • MMP 18 antibody
    • MMP 19 antibody
    • MMP-18 antibody
    • MMP-19 antibody
    • MMP18 antibody
    • MMP19 antibody
    • MMP19_HUMAN antibody
    • RASI 1 antibody
    • RASI antibody
    • RASI1 antibody
    see all

Anti-MMP19 antibody 画像

  • Anti-MMP19 antibody (ab89689) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 57 kDa
  • All lanes : Anti-MMP19 antibody (ab89689) at 1 µg/ml

    Lane 1 : cell lysate from MMP19 transfected 293T cells
    Lane 2 : cell lysate from non transfected 293T cells

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 57 kDa
    Observed band size : 57 kDa

Anti-MMP19 antibody (ab89689) 使用論文

ab89689 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab89689.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"