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機能
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
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組織特異性
Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.
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関連疾患
May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.
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配列類似性
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.
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ドメイン
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
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翻訳後修飾
Activated by autolytic cleavage after Lys-97.
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細胞内局在
Secreted > extracellular space > extracellular matrix.
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Information by UniProt
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参照データベース
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別名
- Matrix metalloproteinase 18 antibody
- Matrix metalloproteinase 19 antibody
- Matrix metalloproteinase RASI antibody
- Matrix metalloproteinase-18 antibody
- Matrix metalloproteinase-19 antibody
- MMP 18 antibody
- MMP 19 antibody
- MMP-18 antibody
- MMP-19 antibody
- MMP18 antibody
- MMP19 antibody
- MMP19_HUMAN antibody
- RASI 1 antibody
- RASI antibody
- RASI1 antibody
see all