製品の概要

  • 製品名Anti-MMP17 antibody
    MMP17 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MMP17
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit
  • 免疫原

    Synthetic peptide:

    KDNNVEEGYPRPVSD

    conjugated to KLH, corresponding to amino acids 409-423 of Human MMP17

  • ポジティブ・コントロール
    • Human Small Intestine tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115761 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
  • 組織特異性Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
  • 配列類似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻訳後修飾The precursor is cleaved by a furin endopeptidase.
  • 細胞内局在Cell membrane. Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Matrix metalloproteinase 17 antibody
    • Matrix metalloproteinase 17 membrane inserted antibody
    • Matrix metalloproteinase-17 antibody
    • Membrane type 4 matrix metalloproteinase antibody
    • Membrane type matrix metalloproteinase 4 antibody
    • Membrane-type matrix metalloproteinase 4 antibody
    • Membrane-type-4 matrix metalloproteinase antibody
    • MMP 17 antibody
    • MMP-17 antibody
    • Mmp17 antibody
    • MMP17_HUMAN antibody
    • MT MMP 4 antibody
    • MT MMP4 antibody
    • MT-MMP 4 antibody
    • MT4 MMP antibody
    • MT4-MMP antibody
    • MT4MMP antibody
    • MTMMP 4 antibody
    • MTMMP4 antibody
    see all

Anti-MMP17 antibody 画像

  • Human Small Intestine (formalin-fixed, paraffin-embedded) stained with ab115761 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MMP17 antibody (ab115761) 使用論文

ab115761 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"