製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MMP16
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthesized peptide derived from human MMP16.

  • ポジティブ・コントロール
    • HepG2 cell extracts; Human brain tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53145 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 57 kDa.
ELISA 1/10000.

ターゲット情報

  • 機能
    Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
  • 組織特異性
    Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
  • 配列類似性
    Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • 発生段階
    Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
  • ドメイン
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻訳後修飾
    The precursor is cleaved by a furin endopeptidase.
  • 細胞内局在
    Cell membrane. Localized at the cell surface of melanoma cells and Secreted > extracellular space > extracellular matrix. Cell surface. Localized at the cell surface of melanoma cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C8orf57 antibody
    • DKFZp761D112 antibody
    • Matrix metalloproteinase 16 antibody
    • Matrix metalloproteinase-16 antibody
    • Membrane type 3 matrix metalloproteinase antibody
    • Membrane type matrix metalloproteinase 3 antibody
    • Membrane-type matrix metalloproteinase 3 antibody
    • Membrane-type-3 matrix metalloproteinase antibody
    • MMP 16 antibody
    • MMP-16 antibody
    • MMP-X2 antibody
    • MMP16 antibody
    • MMP16_HUMAN antibody
    • MT-MMP 3 antibody
    • MT-MMP2 antibody
    • MT-MMP3 antibody
    • MT3-MMP antibody
    • MT3MMP antibody
    • MTMMP2 antibody
    • MTMMP3 antibody
    • Putative transmembrane protein C8orf57 antibody
    see all

Anti-MMP16 antibody 画像

  • All lanes : Anti-MMP16 antibody (ab53145) at 1/500 dilution

    Lane 1 : HepG2 cell extract
    Lane 2 : HepG2 cell extract with immunizing peptide


    Predicted band size : 57 kDa

プロトコール

Anti-MMP16 antibody (ab53145) 使用論文

This product has been referenced in:
  • Hadchouel A  et al. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. PLoS ONE 3:e3188 (2008). WB ; Human . Read more (PubMed: 18784838) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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