The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 76 kDa (predicted molecular weight: 76 kDa).
機能Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
組織特異性Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
配列類似性Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains.
ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
翻訳後修飾The precursor is cleaved by a furin endopeptidase.