製品の概要

  • 製品名Anti-MMP14 antibody
    MMP14 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MMP14
  • 特異性ab72685 detects endogenous levels of fragment of activated MMP14 resulting from cleavage adjacent to Tyr112.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from human MMP14.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab72685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 66 kDa (predicted molecular weight: 66 kDa).
ELISA 1/20000.

ターゲット情報

  • 機能Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.
  • 組織特異性Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
  • 配列類似性Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻訳後修飾The precursor is cleaved by a furin endopeptidase.
  • 細胞内局在Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Matrix metallopeptidase 14 (membrane inserted) antibody
    • Matrix metalloproteinase 14 antibody
    • Matrix metalloproteinase-14 antibody
    • Membrane type 1 matrix metalloproteinase antibody
    • Membrane type 1 metalloprotease antibody
    • Membrane type matrix metalloproteinase 1 antibody
    • Membrane-type matrix metalloproteinase 1 antibody
    • Membrane-type-1 matrix metalloproteinase antibody
    • MMP 14 antibody
    • MMP X1 antibody
    • MMP-14 antibody
    • MMP-X1 antibody
    • Mmp14 antibody
    • MMP14_HUMAN antibody
    • MMPX1 antibody
    • MT MMP 1 antibody
    • MT-MMP 1 antibody
    • MT1 MMP antibody
    • MT1-MMP antibody
    • MT1MMP antibody
    • MTMMP 1 antibody
    • MTMMP1 antibody
    see all

Anti-MMP14 antibody 画像

  • All lanes : Anti-MMP14 antibody (ab72685) at 1/500 dilution

    Lane 1 : 293 cell extract, treated with etoposide (25uM, 1hour)
    Lane 2 : 293 cell extract, treated with etoposide (25uM, 1hour) with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 66 kDa
    Observed band size : 66 kDa
    Additional bands at : 24 kDa,30 kDa. We are unsure as to the identity of these extra bands.

Anti-MMP14 antibody (ab72685) 使用論文

ab72685 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab72685.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"