The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. Predicted molecular weight: 55 kDa.
Use at an assay dependent concentration.
機能May play an important role in the progression of epithelial malignancies.
組織特異性Specifically expressed in stromal cells of breast carcinomas.
配列類似性Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains.
ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
翻訳後修飾The precursor is cleaved by a furin endopeptidase.
細胞内局在Secreted > extracellular space > extracellular matrix.