製品の概要

  • 製品名Anti-MMACHC antibody
    MMACHC 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MMACHC
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to a sequence within amino acids 1-188 of Human MMACHC (NP_056321).

  • ポジティブ・コントロール
    • 293T and Raji whole cell lysates; HeLa cells; A431, H1299, HeLaS3 and HepG2 cell lines

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab96195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 32 kDa.
ICC/IF 1/100 - 1/200.

ターゲット情報

  • 機能May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
  • 組織特異性Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes.
  • パスウェイCofactor biosynthesis; adenosylcobalamin biosynthesis.
  • 関連疾患Defects in MMACHC are the cause of methylmalonic aciduria and homocystinuria type cblC (MMACHC) [MIM:277400]. MMACHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). Affected individuals may have developmental, hematologic, neurologic, metabolic, ophthalmologic, and dermatologic clinical findings. Although considered a disease of infancy or childhood, some individuals develop symptoms in adulthood.
  • 配列類似性Belongs to the MMACHC family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 1810037K07Rik antibody
    • BOS_3654 antibody
    • cblC antibody
    • DKFZp564I122 antibody
    • FLJ25671 antibody
    • Methylmalonic aciduria (cobalamin deficiency) cblC type with homocystinuria antibody
    • Methylmalonic aciduria and homocystinuria type C protein antibody
    • Methylmalonic aciduria and homocystinuria type C protein homolog antibody
    • MGC134307 antibody
    • MMAC_HUMAN antibody
    • MMACHC antibody
    • OTTHUMP00000009243 antibody
    • RP11 291L19.3 antibody
    • RP23-177C18.3 antibody
    see all

Anti-MMACHC antibody 画像

  • All lanes : Anti-MMACHC antibody (ab96195) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 32 kDa
  • ab96195, at 1/100 dilution, staining MMACHC in paraformaldehyde-fixed HeLa cells by Immunofluorescence. Lower image is merged with DNA probe.

Anti-MMACHC antibody (ab96195) 使用論文

This product has been referenced in:
  • Fofou-Caillierez MB  et al. Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia. Hum Mol Genet N/A:N/A (2013). Read more (PubMed: 23825108) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"