機能Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.
関連疾患Meckel syndrome 1 Bardet-Biedl syndrome 13
配列類似性Contains 1 B9 domain.
細胞内局在Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > microtubule organizing center > centrosome. Localizes at the transition zone, a region between the basal body and the ciliary axoneme.