製品の概要

  • 製品名Anti-MKKS antibody
    MKKS 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to MKKS
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 407-438 of Human MKKS (NP_740754.1, NP_061336.1).

  • ポジティブ・コントロール
    • U251 cell line lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab123980 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab123980 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 62 kDa.

ターゲット情報

  • 機能Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis.
  • 組織特異性Widely expressed in adult and fetal tissues.
  • 関連疾患Defects in MKKS are the cause of McKusick-Kaufman syndrome (MKKS) [MIM:236700]. MKKS is an autosomal recessive developmental disorder. It is characterized by hydrometrocolpos, postaxial polydactyly and congenital heart defects.
    Defects in MKKS are the cause of Bardet-Biedl syndrome type 6 (BBS6) [MIM:209900]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect.
  • 配列類似性Belongs to the TCP-1 chaperonin family.
  • ドメインThe substrate-binding apical domain region is sufficient for centrosomal association.
  • 細胞内局在Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytosol. The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Bardet Biedl syndrome 6 protein antibody
    • Bardet-Biedl syndrome 6 protein antibody
    • BBS6 antibody
    • HMCS antibody
    • KMS antibody
    • McKusick Kaufman syndrome antibody
    • McKusick Kaufman/Bardet Biedl syndromes putative chaperonin antibody
    • McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin antibody
    • Mkks antibody
    • MKKS_HUMAN antibody
    • MKS antibody
    see all

Anti-MKKS antibody 画像

  • Anti-MKKS antibody (ab123980) at 1/100 dilution + U251 cell line lysate at 35 µg

    Predicted band size : 62 kDa

Anti-MKKS antibody (ab123980) 使用論文

ab123980 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"