Anti-PDK1 抗体 (ab90444)
Key features and details
- Rabbit polyclonal to PDK1
- Suitable for: WB
- Reacts with: Mouse, Rat, Rabbit, Dog, Human, Pig, African green monkey
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-PDK1 antibody
PDK1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PDK1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat, Rabbit, Dog, Human, Pig, African green monkey -
免疫原
Synthetic peptide corresponding to Human PDK1 conjugated to keyhole limpet haemocyanin.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.09% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab90444の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000. Predicted molecular weight: 49 kDa.
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特記事項 |
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WB
1/1000. Predicted molecular weight: 49 kDa. |
ターゲット情報
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機能
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. -
組織特異性
Expressed predominantly in the heart. -
配列類似性
Belongs to the PDK/BCKDK protein kinase family.
Contains 1 histidine kinase domain. -
細胞内局在
Mitochondrion matrix. - Information by UniProt
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参照データベース
- Entrez Gene: 5163 Human
- Entrez Gene: 228026 Mouse
- Entrez Gene: 100286871 Pig
- Entrez Gene: 116551 Rat
- Omim: 602524 Human
- SwissProt: Q15118 Human
- SwissProt: Q8BFP9 Mouse
- SwissProt: Q63065 Rat
see all -
別名
- [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial antibody
- HGNC:8809 antibody
- Mitochondrial pyruvate dehydrogenase kinase isoenzyme 1 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab90444 は 8 報の論文で使用されています。
- Wang H et al. PD-L1, PDK-1 and p-Akt are correlated in patients with papillary thyroid carcinoma. Adv Clin Exp Med 29:785-792 (2020). PubMed: 32750756
- Hong SM et al. Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis. J Biol Chem 294:7810-7820 (2019). PubMed: 30923124
- Pendleton AL et al. Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses. Am J Physiol Regul Integr Comp Physiol 317:R513-R520 (2019). PubMed: 31314546
- Shibao S et al. Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model. Neuro Oncol 20:343-354 (2018). PubMed: 29016888
- Gudiksen A et al. Training state and fasting-induced PDH regulation in human skeletal muscle. Pflugers Arch N/A:N/A (2018). PubMed: 29946822
- Bertholdt L et al. Impact of skeletal muscle IL-6 on regulation of liver and adipose tissue metabolism during fasting. Pflugers Arch 470:1597-1613 (2018). PubMed: 30069669
- Gudiksen A et al. Muscle interleukin-6 and fasting-induced PDH regulation in mouse skeletal muscle. Am J Physiol Endocrinol Metab 312:E204-E214 (2017). PubMed: 28028037
- Gudiksen A et al. Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise. PLoS One 11:e0156460 (2016). WB . PubMed: 27327080