Anti-Mineralocorticoid Receptor 抗体 (ab97834)

製品の概要

• 製品名Anti-Mineralocorticoid Receptor antibody
  Mineralocorticoid Receptor 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to Mineralocorticoid Receptor
• アプリケーション適用あり: WBmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Rabbit, Horse, Cat, Dog
• 免疫原

  Synthetic peptide corresponding to a region within N terminal amino acids 1-50 of Human Mineralocorticoid Receptor (NP_000892)

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • HT1080 cell lysate

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファーPreservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • Zinc Finger

  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • Nuclear Hormone Receptors
  • Corticoid

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Corticoid

  • Cardiovascular
  • Atherosclerosis
  • Hypertension
  • Vascular remodelling
  • Hypertrophy

  • Cardiovascular
  • Heart
  • Hypertrophy
  • Other

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
• 組織特異性Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.
• 関連疾患Defects in NR3C2 are a cause of autosomal dominant pseudohypoaldosteronism type I (AD-PHA1) [MIM:177735]. PHA1 is characterized by urinary salt wasting, resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal dominant form that is mild, and the recessive form which is more severe and due to defects in any of the epithelial sodium channel subunits. In AD-PHA1 the target organ defect is confined to kidney. Clinical expression can vary from asymptomatic to moderate. It may be severe at birth, but symptoms remit with age. Familial and sporadic cases have been reported.
  Defects in NR3C2 are a cause of early-onset hypertension with severe exacerbation in pregnancy (EOHSEP) [MIM:605115]. Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion.
• 配列類似性Belongs to the nuclear hormone receptor family. NR3 subfamily.
  Contains 1 nuclear receptor DNA-binding domain.
• ドメインComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
• 翻訳後修飾Phosphorylated.
• 細胞内局在Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.

• Target information above from: UniProt accession P08235 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 475461 Dog
  • Entrez Gene: 4306 Human
  • Omim: 600983 Human
  • SwissProt: P08235 Human
  • Unigene: 163924 Human
  • Unigene: 723668 Human
• 別名
  • Aldosterone receptor antibody
  • MCR antibody
  • MCR_HUMAN antibody

  • MGC133092 antibody
  • Mineralocorticoid receptor antibody
  • MLR antibody
  • MR antibody
  • NR3 C2 antibody
  • NR3C2 antibody
  • NR3C2 protein antibody
  • Nuclear receptor subfamily 3 group C member 2 antibody

  see all